a multicenter study on expressions of vascular endothelial growth factor, matrix metallopeptidase-9 and tissue inhibitor of metalloproteinase-2 in oral and maxillofacial squamous cell carcinoma
نویسندگان
چکیده
conclusions: lymphatic metastasis in patients with oral and maxillofacial scc is closely related to the positive expression of vegf, mmp-9 and timp-2. mmp-9 and timp-2 can affect the progression of cancer, which is valuable for studies on oral and maxillofacial scc genes. objectives: to explore the association between expression of vegf, mmp-9 and timp-2 in oral and maxillofacial scc and clinicopathological factors. patients and methods: immunohistochemical envision method was used to analyze the expression of vegf, mmp-9 and timp-2 in 54 cases of oral and maxillofacial scc and the association with clinicopathological factors such as clinical staging and lymphatic metastasis. results: brownish-yellow staining is correlated with positive expression of vegf, mmp-9 and timp-2. positive expression of vegf and mmp-9 was correlated with lymphatic metastasis, and their positive expression rates were significantly higher in patients with lymphatic metastasis than those without it (vegf: χ2 = 30.00; p = 0.001; mmp-9: χ2 = 18.27, p = 0.001). the positive expression rate of mmp-9 decreased at earlier clinical stages (p < 0.05). positive expression of timp-2 was correlated with lymphatic metastasis, clinical staging and t classification. the positive rate of timp-2 expression in patients with lymphatic metastasis was significantly lower than those without it (χ2 = 26.74, p = 0.002), which significantly reduced with increasing clinical stage and t classification (p < 0.05). background: vascular endothelial growth factor (vegf), matrix metallopeptidase-9 (mmp-9) and tissue inhibitor of metalloproteinase-2 (timp-2) are potential markers of oral and maxillofacial squamous cell carcinoma (scc).
منابع مشابه
A Multicenter Study on Expressions of Vascular Endothelial Growth Factor, Matrix Metallopeptidase-9 and Tissue Inhibitor of Metalloproteinase-2 in Oral and Maxillofacial Squamous Cell Carcinoma
BACKGROUND Vascular endothelial growth factor (VEGF), matrix metallopeptidase-9 (MMP-9) and tissue inhibitor of metalloproteinase-2 (TIMP-2) are potential markers of oral and maxillofacial squamous cell carcinoma (SCC). OBJECTIVES To explore the association between expression of VEGF, MMP-9 and TIMP-2 in oral and maxillofacial SCC and clinicopathological factors. PATIENTS AND METHODS Immuno...
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عنوان ژورنال:
iranian red crescent medical journalجلد ۱۶، شماره ۳، صفحات ۰-۰
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